Veterinary Microbiology and Microbial Disease - Quinn P.J., Markey B.K.

Veterinary Microbiology and Microbial Disease - Quinn P.J., Markey B.K.Год выпуска: 2002

Автор: Quinn P.J., Markey B.K.

Жанр: Ветеринария

Формат: PDF

Качество: OCR

Описание: The pace of change in microbiology has accelerated in recent years as molecular techniques, applied to microbial pathogens, elucidate the pathogenesis of many infectious diseases and improve the reliability of diagnostic test procedures. Today, microbiology occupies a central position in the veterinary curriculum and has developed into a subject of vast complexity. Since the publication of Veterinary Microbiology and Microbial Disease in 2002, many changes have occurred in veterinary microbiology, some on the recommendations of international committees and others as a consequence of relevant research.
The second edition of our book incorporates changes in individual chapters which have been updated and expanded. In addition, new chapters on immunodeficiency diseases, vaccines and vaccination, molecular diagnostic methods, antibacterial resistance, antifungal chemotherapy, antiviral chemotherapy and microbial diseases of the urinary tract, cardiovascular system, musculoskeletal system and the integumentary system have been added.
This edition is divided into seven sections. The first section provides an introduction to microbiology, infection, immunity and molecular diagnostic methods. Section II contains chapters on introductory bacteriology. Pathogenic bacteria are dealt with in Section III. The twelve chapters in Section IV are concerned with mycology. Introductory virology is presented in Section V. Viruses and prions are covered in Section VI. The final section, Section VII, includes chapters on the interactions of microbial pathogens with body systems. A separate chapter in this section deals with bovine mastitis and the final chapter provides a comprehensive review of disinfection, biosecurity and other aspects of disease control.
To facilitate readers requiring additional information on topics included in the book, a list of websites is provided at the end of Section VII.
The use of colour in this edition enhances the quality of the illustrations and facilitates the interpretation of complex diagrams.
The authors would be pleased to receive notification of errors or inaccuracies in this edition of our book.


«Veterinary Microbiology and Microbial Disease»

Introduction to Microbiology Infection Immunity and Molecular Diagnostic Methods

  1. Microbiology microbial pathogens and infectious disease
    • Further reading
  2. Subdivisions classification and morphological characterization of infectious agents
    • Microscopical techniques
    • Pathogenic microorganisms
    • Biological classification and nomenclature
  3. Infection and immunity
    • Normal flora
    • Comparative aspects of innate and adaptive immunity
    • Recognition of pathogens
    • Cells involved in innate immune responses
    • Complement
    • Adaptive immunity
    • Immunity to bacteria
    • Immunity to fungi
    • Immunity to viruses
    • Concluding comments
  4. Immunodeficiency diseases
    • Severe combined immunodeficiency diseases
    • Thymic aplasia or hypoplasia
    • Wiskott-Aldrich syndrome
    • Primary immunodeficiency diseases involving B lymphocytes
    • Secondary immunodeficiency
  5. Vaccines and vaccination
    • Vaccination
    • Inactivated vaccines
    • Live attenuated vaccines
    • Vaccines produced by recombinant nucleic acid technology
    • Synthetic peptide vaccines
    • DNA vaccines
    • Reverse vaccinology
    • Adjuvants
    • Administration of vaccines
    • Adverse reactions following vaccination
    • Vaccination failure
    • References
  6. Molecular diagnostic methods
    • Analytical properties of nucleic acid
    • Molecular hybridization
    • DNA sequencing
    • Polymerase chain reaction (PCR)
    • Real-time PCR
    • Diagnostic approaches to surveillance and subtyping of bacteria a comparison of phenotyping and genotyping methods
    • Molecular subtyping for definitive identification of bacteria
    • Plasmid profiling
    • Restriction endonuclease analysis (REA)
    • Ribotyping
    • Pulsed-field gel electrophoresis (PFGE)
    • PCR-based subtyping methods
    • Multilocus sequence typing (MLST)
    • DNA microarray technology
    • Whole bacterial genome sequencing
    • References

Introductory Bacteriology

  1. 7 The structure of bacterial cells
    • Capsule
    • Cell wall
    • Cytoplasmic membrane
    • Cytoplasm
    • Ribosomes
    • Nuclear material
    • Flagella
    • Pili
    • Biofilms
    • Protein secretion systems
    • Endospores
  2. Cultivation preservation and inactivation of bacteria
    • Bacterial growth
    • Bacterial nutrition
    • Physical and chemical factors which influence growth
    • Preservation of microorganisms
    • Physical methods for inactivating microorganisms
    • Biosafety cabinets
  3. Bacterial genetics mechanisms of genetic variation and gene databases
    • Replication of bacterial DNA
    • Transcription and translation the expression of genetic information
    • Mechanisms contributing to genetic variation
    • Examples of mobile genetic elements
    • Genetic engineering of bacteria in the laboratory
    • Genetic databases and bioinformatics
  4. Laboratory diagnosis of bacterial disease
    • Selection collection and transportation of specimens
    • Identification of pathogenic bacteria
    • Serology
  5. Antibacterial agents
    • Development of chemotherapy for bacterial infections
    • Mode and site of action
    • Combined antibacterial therapy
    • Factors influencing a ntibacterial activity
  6. Antibacterial resistance
    • Resistance mechanisms
    • Multiple drug resistance
    • Strategies for limiting a ntibacterial resistance
    • Antibacterial susceptibility testing
  7. Bacterial colonization tissue invasion and clinical disease
    • Commensals
    • Pathogens
    • Colonization and growth
    • Pathogen-host interactions
    • Virulence factors
    • Responses of the host to bacterial pathogens
    • The clinical spectrum of bacterial disease

Pathogenic Bacteria

  1. Staphylococcus species
  2. Streptococci
  3. Actinobacteria
  4. Corynebacterium species
  5. Rhodococcus equi
  6. Listeria species
  7. Erysipelothrix rhusiopathiae
  8. Bacillus species
  9. Clostridium species
  10. Mycobacterium species
  11. Enterobacteriaceae
  12. Pseudomonas aeruginosa and Burkholderia species
  13. Actinobacillus species
  14. Pasteurella species Mannheimia haemolytica and Bibersteinia trehalosi
  15. Francisella tularensis
  16. Histophilus somni Haemophilus parasuis and Avibacterium paragallinarum
  17. Taylorella species
  18. Bordetella species
  19. Moraxella species
  20. Brucella species
  21. Campylobacter and Helicobacter species
  22. Lawsonia intracellularis
  23. Spirochaetes
  24. Pathogenic anaerobic non-spore-forming Gram-negative bacteria
  25. Mycoplasmas
  26. Chlamydia and Chlamydophila species
  27. Rickettsiales and Coxiella burnetii
  28. Bacterial species of limited pathogenic significance


  1. General features of fungi associated with disease in animals
  2. Dermatophytes
  3. Aspergillus species
  4. Yeasts and disease production
  5. Dimorphic fungi
  6. Zygomycetes of veterinary importance
  7. Fungus-like organisms of veterinary importance
  8. Pneumocystis carinii
  9. Opportunistic infections caused predominantly by phaeoid fungi
  10. Mycotoxins and mycotoxicoses
  11. Pathogenic algae and cyanobacteria
  12. Antifungal chemotherapy

Introductory Virology

  1. Nature structure and taxonomy of viruses
  2. Replication of viruses
  3. Genetics and evolution of viruses
  4. Propagation of viruses and virus-cell interactions
  5. Pathogenesis of viral diseases
  6. Laboratory diagnosis of viral infections
  7. Antiviral chemotherapy

Viruses and Prions

  1. Herpesviridae
  2. Papillomaviridae
  3. Adenoviridae
  4. Poxviridae
  5. Asfarviridae
  6. Parvoviridae
  7. Circoviridae
  8. Retroviridae
  9. Reoviridae
  10. Birnaviridae
  11. Orthomyxoviridae
  12. Paramyxoviridae
  13. Rhabdoviridae
  14. Bornaviridae
  15. Bunyaviridae
  16. Picornaviridae
  17. Caliciviridae
  18. Astroviridae
  19. Coronaviridae
  20. Arteriviridae
  21. Flaviviridae
  22. Togaviridae
  23. Prions: unconventional infectious agents

Microbial Agents and Disease Production

  1. Tissue and system preferences of bacterial fungal and viral pathogens and the nature of the diseases caused by these infectious agents
  2. Interactions of microbial pathogens with the nervous system
  3. Interactions of microbial pathogens with the male and female reproductive systems
  4. The role of microbial pathogens in intestinal disease
  5. The role of microbial pathogens in respiratory disease
  6. Interactions of microbial pathogens with the renal system
  7. Microbial diseases of the cardiovascular system
  8. Interactions of microbial pathogens with the musculoskeletal system
  9. The role of microbial pathogens in diseases of the integumentary system
  10. Bacterial causes of bovine mastitis
  11. Disinfection biosecurity and other aspects of disease control
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